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Isaiah J Fidler Selected Research

AEE 788 (AEE788)

1/2008Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy.
12/2007Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice.
10/2007Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.
12/2006Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells.
9/2006Targeting receptor tyrosine kinase on lymphatic endothelial cells for the therapy of colon cancer lymph node metastasis.
11/2005Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.
7/2005Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.
7/2005Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors.
6/2005Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor receptor phosphorylation.
5/2005Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
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Isaiah J Fidler Research Topics

Disease

99Neoplasms (Cancer)
04/2016 - 01/2002
54Neoplasm Metastasis (Metastasis)
04/2016 - 01/2002
16Pancreatic Neoplasms (Pancreatic Cancer)
07/2013 - 04/2002
14Carcinoma (Carcinomatosis)
02/2012 - 01/2002
14Prostatic Neoplasms (Prostate Cancer)
07/2011 - 10/2002
13Lymphatic Metastasis
07/2011 - 10/2002
11Lung Neoplasms (Lung Cancer)
04/2016 - 06/2002
10Brain Neoplasms (Brain Tumor)
04/2016 - 01/2002
10Melanoma (Melanoma, Malignant)
07/2015 - 01/2002
10Colonic Neoplasms (Colon Cancer)
07/2008 - 05/2003
8Breast Neoplasms (Breast Cancer)
04/2016 - 01/2005
8Ovarian Neoplasms (Ovarian Cancer)
02/2012 - 06/2002
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2016 - 06/2002
4Adenocarcinoma of Lung
10/2007 - 06/2002
3Renal Cell Carcinoma (Grawitz Tumor)
06/2006 - 11/2002
3Mouth Neoplasms (Oral Cancer)
11/2004 - 08/2002
3Head and Neck Neoplasms (Head and Neck Cancer)
11/2004 - 08/2002
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2003 - 06/2002
2Osteosarcoma (Osteogenic Sarcoma)
01/2019 - 11/2002
2Ascites
02/2011 - 08/2002
2Carcinogenesis
02/2010 - 02/2010
2Tongue Neoplasms (Tongue Neoplasm)
08/2003 - 01/2002
1Glioblastoma (Glioblastoma Multiforme)
10/2015
1Glioma (Gliomas)
10/2015

Drug/Important Bio-Agent (IBA)

28ErbB Receptors (EGF Receptor)IBA
07/2008 - 04/2002
23Paclitaxel (Taxol)FDA LinkGeneric
04/2016 - 07/2002
19Epidermal Growth Factor (EGF)IBA
02/2008 - 04/2002
18Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
01/2009 - 11/2002
16Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2015 - 04/2002
15Imatinib Mesylate (Gleevec)FDA Link
01/2019 - 11/2002
14Tyrosine Kinase InhibitorsIBA
01/2019 - 04/2002
13PKI 166IBA
05/2008 - 04/2002
13Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
02/2008 - 04/2002
11Biological ProductsIBA
12/2015 - 07/2002
11AEE 788 (AEE788)IBA
01/2008 - 11/2004
10Transforming Growth Factor alpha (TGF-alpha)IBA
07/2008 - 07/2002
9Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
02/2008 - 04/2002
9GemcitabineFDA Link
07/2006 - 04/2002
7Proteins (Proteins, Gene)FDA Link
04/2016 - 01/2004
7Therapeutic UsesIBA
12/2015 - 03/2003
6Platelet-Derived Growth FactorIBA
01/2019 - 11/2002
6LigandsIBA
02/2008 - 12/2003
5Interleukin-8 (Interleukin 8)IBA
12/2014 - 11/2002
5Docetaxel (Taxotere)FDA Link
01/2009 - 10/2002
5Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
05/2008 - 01/2004
5Phosphotransferases (Kinase)IBA
05/2008 - 01/2005
5Irinotecan (Camptosar)FDA LinkGeneric
05/2008 - 05/2005
5Matrix Metalloproteinases (MMPs)IBA
11/2007 - 08/2002
5Proliferating Cell Nuclear Antigen (PCNA)IBA
06/2003 - 04/2002
4Endothelin Receptors (Endothelin Receptor)IBA
04/2016 - 02/2011
4Endothelins (Endothelin)IBA
04/2016 - 02/2012
4macitentanIBA
04/2016 - 02/2011
4Endothelin Receptor AntagonistsIBA
10/2015 - 02/2011
4Mitogen-Activated Protein KinasesIBA
12/2014 - 04/2004
4Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2008 - 07/2002
4platelet-derived growth factor AIBA
12/2006 - 12/2003
3Glucose (Dextrose)FDA LinkGeneric
02/2015 - 05/2008
3Interleukin-6 (Interleukin 6)IBA
12/2014 - 12/2005
3Small Interfering RNA (siRNA)IBA
07/2011 - 05/2008
3AndrogensIBA
01/2009 - 03/2003
3CytokinesIBA
09/2006 - 10/2003
3Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
06/2005 - 07/2002
3Cadherins (E-Cadherin)IBA
06/2005 - 11/2002
3Messenger RNA (mRNA)IBA
06/2005 - 11/2002
3Formaldehyde (Formol)FDA Link
01/2004 - 01/2002
3Interferon-betaIBA
05/2003 - 07/2002
3Interferon-alpha (Interferon Alfa)IBA
05/2003 - 01/2002
2AgarIBA
09/2011 - 05/2011
2Biomarkers (Surrogate Marker)IBA
04/2011 - 11/2005
2InterferonsIBA
12/2010 - 05/2003
2Green Fluorescent ProteinsIBA
12/2010 - 05/2009
2Transforming Growth Factor beta (TGF-beta)IBA
02/2009 - 09/2002
2taxaneIBA
01/2009 - 10/2007
2Prostate-Specific Antigen (Semenogelase)IBA
01/2009 - 06/2003
2human ERBB2 proteinIBA
05/2008 - 12/2007
2Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
02/2008 - 01/2008
2Growth Factor ReceptorsIBA
02/2008 - 06/2005
2Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA
01/2008 - 12/2003
2Pharmaceutical PreparationsIBA
03/2007 - 05/2005
2Indicators and Reagents (Reagents)IBA
11/2005 - 07/2005
2Serum Amyloid A Protein (Serum Amyloid A)IBA
11/2005 - 02/2005
2NF-kappa B (NF-kB)IBA
01/2005 - 04/2004
2DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
08/2003 - 05/2003
2ParaffinIBA
11/2002 - 01/2002
1Temozolomide (Temodar)FDA LinkGeneric
10/2015
1Culture MediaIBA
05/2015
1Bovine Serum AlbuminIBA
05/2015
1InosineFDA Link
03/2015
1immune RNA (I-RNA)IBA
03/2015
1Adenosine (Adenocard)FDA LinkGeneric
03/2015
1MicroRNAs (MicroRNA)IBA
03/2015
1purineIBA
02/2015

Therapy/Procedure

61Therapeutics
04/2016 - 01/2002
17Drug Therapy (Chemotherapy)
04/2016 - 04/2002
6Oral Administration
07/2006 - 11/2002
6Injections
06/2004 - 08/2002
3Prostatectomy (Retropubic Prostatectomy)
01/2009 - 06/2003
3Immunotherapy
05/2007 - 08/2002
2Intravenous Injections
07/2006 - 01/2002
2Molecular Targeted Therapy
08/2003 - 08/2002